HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | Gag(162-172) | Gag Epitope Map
View variants at this location |
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| Epitope |
KAFSPEVIPMF
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Epitope Alignment | ||||
| Variants |
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| Epitope Name | KAFS | |||||
| Species (MHC/HLA) | human(B*57:01, B*57:03) | |||||
Showing 1 of 8 variants.
| Variant ID. | 347 |
|---|---|
| Epitope Seq. | KAFSPEVIPMF |
| Variant Seq. | KgFnPEVIPMF |
| Mutations | A/G S/N |
| Epitope Location | A2G S4N |
| HXB2 Location | A163G S165N |
| Mutation Type | SSF: subtype-specific susceptible form |
| Epitope Subtype | B |
| Variant Subtype | A, AC |
| Method | CD8 T-cell Elispot - IFNy, Chromium-release assay, Tetramer binding |
| Note | Variant found in clades A and AC. B*5701 CTL clones recognized this variant and displayed similar levels of lytic activity as against the wt at time 0 but 50% of activity at 24h later. This variant was presented more efficiently by B*5703 than by B*5701. The variant reacted with 100% of CTLs but failed to induce significant IFN-gamma secretion in 2 of the patients, indicating that this variant is unable to activate all downstream effector functions. However, it induced IFN-gamma in some patients' PBMCs. |
Gillespie2002 Geraldine M. A. Gillespie, Rupert Kaul, Tao Dong, Hong-Bing Yang, Tim Rostron, Job J. Bwayo, Peter Kiama, Tim Peto, Francis A. Plummer, Andrew J. McMichael, and Sarah L. Rowland-Jones. Cross-Reactive Cytotoxic T Lymphocytes against a HIV-1 P24 Epitope in Slow Progressors with B*57. AIDS, 16(7):961-972, 3 May 2002. PubMed ID: 11953462. Show all entries for this paper.