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Displaying record number 59383

HXB2 Location Gag(25-34) Gag Epitope Map
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Epitope

GKKPYMLKHL

Epitope Alignment

Variants

GKKsYMLKHL diminished response; escape documented in this paper

Species (MHC/HLA) human

Variant Details

Showing 1 of 2 variants.

Variant ID.	`3463`
Epitope Seq.	`GKKPYMLKHL`
Variant Seq.	`GKKsYMLKHL`
Mutations	P/S
Epitope Location	P4S
HXB2 Location	P28S
Mutation Type	DR: diminished response E: escape documented in this paper
Epitope Subtype	C
Variant Subtype	C
Method	CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note	Variant GKKsYMLKHL was present in the patient's sequences and had a greatly diminished response as compared to wt epitope.

References

Ritchie2014 Adam John Ritchie, Fangping Cai, Nicola M. G. Smith, Sheri Chen, Hongshuo Song, Simon Brackenridge, Salim S. Abdool Karim, Bette T. Korber, Andrew J. McMichael, Feng Gao, and Nilu Goonetilleke. Recombination-Mediated Escape from Primary CD8+ T Cells in Acute HIV-1 Infection. Retrovirology, 11:69, 2014. PubMed ID: 25212771. Show all entries for this paper.