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Found 1 matching record:

Displaying record number 59383

HXB2 Location  Gag(25-34)   Gag Epitope Map
View variants at this location
Epitope GKKPYMLKHL   Epitope Alignment
Variants
GKKsYMLKHL   diminished response; escape documented in this paper
Species (MHC/HLA human

Variant Details

Showing 1 of 2 variants.


Variant ID.  3463
Epitope Seq.  GKKPYMLKHL
Variant Seq.  GKKsYMLKHL
Mutations P/S
Epitope Location P4S
HXB2 Location P28S
Mutation Type DR: diminished response
E: escape documented in this paper
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay, Sequence
Note Variant GKKsYMLKHL was present in the patient's sequences and had a greatly diminished response as compared to wt epitope.

References

Ritchie2014 Adam John Ritchie, Fangping Cai, Nicola M. G. Smith, Sheri Chen, Hongshuo Song, Simon Brackenridge, Salim S. Abdool Karim, Bette T. Korber, Andrew J. McMichael, Feng Gao, and Nilu Goonetilleke. Recombination-Mediated Escape from Primary CD8+ T Cells in Acute HIV-1 Infection. Retrovirology, 11:69, 2014. PubMed ID: 25212771. Show all entries for this paper.


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