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Found 1 matching record:

Displaying record number 59380

HXB2 Location  Gag(162-172)   Gag Epitope Map
View variants at this location
Epitope KAFSPEVIPMF   Epitope Alignment
Variants
KgFSPEVIPMF   literature escape; replicative capacity reduced; subtype-specific non-susceptible form
Epitope Name KF11
Species (MHC/HLA human(B*57:01, B*57:03)

Variant Details

Showing 1 of 14 variants.


Variant ID.  3458
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KgFSPEVIPMF
Mutations A/G
Epitope Location A2G
HXB2 Location A163G
Mutation Type LE: literature escape
RCR: replicative capacity reduced
SNSF: subtype-specific non-susceptible form
Epitope Subtype B, C
Variant Subtype B, C
Method CD8 T-cell Elispot - IFNy, Relative replication capacity assay, TCR binding
Note Escape variants A163G and S165N are selected in ˜70% of C-infected B*5703-positive subjects, but are not found in B-infected B*5703-positive subjects. The introduction of either or both of these mutations decreases viral replication. There were observable clade-specific differences between C-clade (Botswana) and B-clade (Barbados) 163G.

References

Payne2014 R. P. Payne, S. Branch, H Kløverpris, P. C. Matthews, C. K. Koofhethile, T. Strong, E. Adland, E. Leitman, J. Frater, T. Ndung'u, E. Hunter, R. Haubrich, B. Mothe, A. Edwards, L. Riddell, F. Chen, P. R. Harrigan, Z. L. Brumme, S. Mallal, M. John, J. P. Jooste, R. Shapiro, S. G. Deeks, B. D. Walker, C. Brander, C. Landis, J. M. Carlson, J. G. Prado, and P. J. R. Goulder. Differential Escape Patterns within the Dominant HLA-B*57:03-Restricted HIV Gag Epitope Reflect Distinct Clade-Specific Functional Constraints. J. Virol., 88(9):4668-4678, May 2014. PubMed ID: 24501417. Show all entries for this paper.


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