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Found 1 matching record:

Displaying record number 54597

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLYNTVATL   Epitope Alignment
Variants
SLfNTiATL   diminished response
Species (MHC/HLA human(A2, A68)

Variant Details

Showing all: 1 variant(s).


Variant ID.  341
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNTiATL
Mutations Y/F V/I
Epitope Location Y3F V6I
HXB2 Location Y79F V82I
Mutation Type DR: diminished response
Epitope Subtype C
Variant Subtype A, D
Note The wild type epitope sequence was a subtype C peptide, the variant common to subtypes A and D. CTL response in 56 individuals from Tanzania was strongest for subtype C peptide, and lower for subtypes A and D, due to point mutation effect.

References

Geldmacher2007 Christof Geldmacher, Jeffrey R. Currier, Martina Gerhardt, Antelmo Haule, Leonard Maboko, Deborah Birx, Clive Gray, Andreas Meyerhans, Josephine Cox, and Michael Hoelscher. In a Mixed Subtype Epidemic, the HIV-1 Gag-Specific T-Cell Response Is Biased Towards the Infecting Subtype. AIDS, 21(2):135-143, 11 Jan 2007. PubMed ID: 17197803. Show all entries for this paper.


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