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Displaying record number 54596

HXB2 Location Gag(28-36) Gag Epitope Map
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Epitope

HYMLKHIVW

Epitope Alignment

Variants

qYrmKHlVW diminished response

Species (MHC/HLA) human(A*23:01)

Variant Details

Showing 1 of 2 variants.

Variant ID.	`340`
Epitope Seq.	`HYMLKHIVW`
Variant Seq.	`qYrmKHlVW`
Mutations	H/Q M/R L/M I/L
Epitope Location	H1Q M3R L4M I7L
HXB2 Location	H28Q M30R L31M I34L
Mutation Type	DR: diminished response
Epitope Subtype	C
Variant Subtype	A
Note	The wild type epitope sequence was a subtype C peptide, the variant found in subtype A. CTL response in 56 individuals from Tanzania was strongest for subtype C peptide, and lower for subtype A, due to point mutation effect.

References

Geldmacher2007 Christof Geldmacher, Jeffrey R. Currier, Martina Gerhardt, Antelmo Haule, Leonard Maboko, Deborah Birx, Clive Gray, Andreas Meyerhans, Josephine Cox, and Michael Hoelscher. In a Mixed Subtype Epidemic, the HIV-1 Gag-Specific T-Cell Response Is Biased Towards the Infecting Subtype. AIDS, 21(2):135-143, 11 Jan 2007. PubMed ID: 17197803. Show all entries for this paper.