HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


Found 1 matching record:

Displaying record number 54596

HXB2 Location  Gag(28-36)   Gag Epitope Map
View variants at this location
Epitope HYMLKHIVW   Epitope Alignment
qYrmKHlVW   diminished response
Species (MHC/HLA human(A*23:01)

Variant Details

Showing 1 of 2 variants.

Variant ID.  340
Epitope Seq.  HYMLKHIVW
Variant Seq.  qYrmKHlVW
Mutations H/Q M/R L/M I/L
Epitope Location H1Q M3R L4M I7L
HXB2 Location H28Q M30R L31M I34L
Mutation Type DR: diminished response
Epitope Subtype C
Variant Subtype A
Note The wild type epitope sequence was a subtype C peptide, the variant found in subtype A. CTL response in 56 individuals from Tanzania was strongest for subtype C peptide, and lower for subtype A, due to point mutation effect.


Geldmacher2007 Christof Geldmacher, Jeffrey R. Currier, Martina Gerhardt, Antelmo Haule, Leonard Maboko, Deborah Birx, Clive Gray, Andreas Meyerhans, Josephine Cox, and Michael Hoelscher. In a Mixed Subtype Epidemic, the HIV-1 Gag-Specific T-Cell Response Is Biased Towards the Infecting Subtype. AIDS, 21(2):135-143, 11 Jan 2007. PubMed ID: 17197803. Show all entries for this paper.

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