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Found 1 matching record:

Displaying record number 54596

HXB2 Location  Gag(28-36)   Gag Epitope Map
View variants at this location
Epitope HYMLKHIVW   Epitope Alignment
Variants
kYrLKHlVW   diminished response
Species (MHC/HLA human(A*23:01)

Variant Details

Showing 1 of 2 variants.


Variant ID.  339
Epitope Seq.  HYMLKHIVW
Variant Seq.  kYrLKHlVW
Mutations H/K M/R I/L
Epitope Location H1K M3R I7L
HXB2 Location H28K M30R I34L
Mutation Type DR: diminished response
Epitope Subtype C
Variant Subtype D
Note The wild type epitope sequence was a subtype C peptide, the variant found in subtype D. CTL response in 56 individuals from Tanzania was strongest for subtype C peptide, and lower for subtype D, due to point mutation effect.

References

Geldmacher2007 Christof Geldmacher, Jeffrey R. Currier, Martina Gerhardt, Antelmo Haule, Leonard Maboko, Deborah Birx, Clive Gray, Andreas Meyerhans, Josephine Cox, and Michael Hoelscher. In a Mixed Subtype Epidemic, the HIV-1 Gag-Specific T-Cell Response Is Biased Towards the Infecting Subtype. AIDS, 21(2):135-143, 11 Jan 2007. PubMed ID: 17197803. Show all entries for this paper.


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