HIV molecular immunology database

 

Search the Epitope Variant and Escape Mutation Database

Help


Found 1 matching record:

Displaying record number 54602

HXB2 Location  Gag(22-29)   Gag Epitope Map
View variants at this location
Epitope RPGGKKHY   Epitope Alignment
Variants
RPGGKKqY   diminished response
Species (MHC/HLA human(B42, B7)

Variant Details

Showing 1 of 2 variants.


Variant ID.  338
Epitope Seq.  RPGGKKHY
Variant Seq.  RPGGKKqY
Mutations H/Q
Epitope Location H7Q
HXB2 Location H28Q
Mutation Type DR: diminished response
Epitope Subtype C
Variant Subtype A
Note The wild type epitope sequence was a subtype C peptide, the variant found in subtype A. CTL response in 56 individuals from Tanzania was strongest for subtype D peptide, and lower for subtype A, due to point mutation effect.

References

Geldmacher2007 Christof Geldmacher, Jeffrey R. Currier, Martina Gerhardt, Antelmo Haule, Leonard Maboko, Deborah Birx, Clive Gray, Andreas Meyerhans, Josephine Cox, and Michael Hoelscher. In a Mixed Subtype Epidemic, the HIV-1 Gag-Specific T-Cell Response Is Biased Towards the Infecting Subtype. AIDS, 21(2):135-143, 11 Jan 2007. PubMed ID: 17197803. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health