HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


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Displaying record number 59230

HXB2 Location  Gag(148-156)   Gag Epitope Map
View variants at this location
Epitope SPRTLNAWV   Epitope Alignment
SPRTLSAWV   susceptible form
Species (MHC/HLA human(B*07:02)

Variant Details

Showing 1 of 5 variants.

Variant ID.  3377
Epitope Seq.  SPRTLNAWV
Variant Seq.  SPRTLSAWV
Mutations N/S
Epitope Location N6S
HXB2 Location N153S
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note Fifth variant to arise; seen in early and late ART period; positive Elispot result in early ART >200 SFC/106PBMC, but no response in late ART.


Melhem2014 Nada M Melhem, Kellie N. Smith, Xiao-Li Huang, Bonnie A Colleton, Weimin Jiang, Robbie B. Mailliard, James I. Mullins, and Charles R. Rinaldo. The Impact of Viral Evolution and Frequency of Variant Epitopes on Primary and Memory Human Immunodeficiency Virus Type 1-Specific CD8+ T Cell Responses. Virology, 450-451:34-48, Feb 2014. PubMed ID: 24503065. Show all entries for this paper.

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