Found 1 matching record:
HXB2 Location | Gag(240-249) | Gag Epitope Map
View variants at this location |
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Epitope |
TSTLQEQIGW
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Epitope Alignment | ||||
Variants |
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Epitope Name | TW10 | |||||
Species (MHC/HLA) | human(B*57:01, B*58) |
Showing 1 of 3 variants.
Variant ID. | 3315 |
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Epitope Seq. | TSTLQEQIGW |
Variant Seq. | TSTLQEQIeW |
Mutations | G/E |
Epitope Location | G9E |
HXB2 Location | G248E |
Mutation Type | DR: diminished response OV: observed variant |
Epitope Subtype | B |
Variant Subtype | B |
Method | Relative replication capacity assay, Sequence |
Note | Mutant TSTLQEQIeW, G248E, was detected in HLA-B*57 subject CH58 at 45 days post infection (dpi), but disappeared after 154 dpi. This mutation is known to modestly reduce CTL response. |
Liu2014a Donglai Liu, Tao Zuo, Bhavna Hora, Hongshuo Song, Wei Kong, Xianghui Yu, Nilu Goonetilleke, Tanmoy Bhattacharya, Alan S. Perelson, Barton F. Haynes, Andrew J. McMichael, and Feng Gao. Preexisting Compensatory Amino Acids Compromise Fitness Costs of a HIV-1 T Cell Escape Mutation. Retrovirology, 11:101, 2014. PubMed ID: 25407514. Show all entries for this paper.
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