logo image

HIV Molecular Immunology Database

Search the Epitope Variant and Escape Mutation Database

Help


Found 1 matching record:

Displaying record number 59194

HXB2 Location  Gag(240-249)   Gag Epitope Map
View variants at this location
Epitope TSTLQEQIGW   Epitope Alignment
Variants
TSTLQEQIeW   diminished response; observed variant
Epitope Name TW10
Species (MHC/HLA human(B*57:01, B*58)

Variant Details

Showing 1 of 3 variants.


Variant ID.  3315
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSTLQEQIeW
Mutations G/E
Epitope Location G9E
HXB2 Location G248E
Mutation Type DR: diminished response
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Relative replication capacity assay, Sequence
Note Mutant TSTLQEQIeW, G248E, was detected in HLA-B*57 subject CH58 at 45 days post infection (dpi), but disappeared after 154 dpi. This mutation is known to modestly reduce CTL response.

References

Liu2014a Donglai Liu, Tao Zuo, Bhavna Hora, Hongshuo Song, Wei Kong, Xianghui Yu, Nilu Goonetilleke, Tanmoy Bhattacharya, Alan S. Perelson, Barton F. Haynes, Andrew J. McMichael, and Feng Gao. Preexisting Compensatory Amino Acids Compromise Fitness Costs of a HIV-1 T Cell Escape Mutation. Retrovirology, 11:101, 2014. PubMed ID: 25407514. Show all entries for this paper.


This is a legacy search page. It is deprecated, will receive no more updates, and will eventually be removed. Please use the new search pages.

Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy's National Nuclear Security Administration
Copyright Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services LANL logo National Institutes of Health logo