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Found 1 matching record:

Displaying record number 53685

HXB2 Location  Gag(74-82)   Gag Epitope Map
View variants at this location
Epitope ELRSLYNTV   Epitope Alignment
Variants
gikSLhNTV   observed variant
Species (MHC/HLA human(B8)

Variant Details

Showing all: 1 variant(s).


Variant ID.  329
Epitope Seq.  ELRSLYNTV
Variant Seq.  gikSLhNTV
Mutations E/G L/I R/K Y/H
Epitope Location E1G L2I R3K Y6H
HXB2 Location E74G L75I R76K Y79H
Mutation Type OV: observed variant
Note Cross-clade T cell responses are frequently induced in individuals infected with different HIV-1 clades. There was an inverse correlation between the height of responses and epitope sequence divergence. For Gag epitopes, the magnitude of the response was directly linked to the homology between HLA anchor residues.

References

Geels2005 Mark J. Geels, Sheri A. Dubey, Kiersten Anderson, Elly Baan, Margreet Bakker, Georgios Pollakis, William A. Paxton, John W. Shiver, and Jaap Goudsmit. Broad Cross-Clade T-Cell Responses to Gag in Individuals Infected with Human Immunodeficiency Virus Type 1 Non-B Clades (A to G): Importance of HLA Anchor Residue Conservation. J. Virol., 79(17):11247-11258, Sep 2005. PubMed ID: 16103177. Show all entries for this paper.


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