HIV molecular immunology database
Found 1 matching record:
|HXB2 Location||Gag(71-79)|| Gag Epitope Map
View variants at this location
Showing all: 1 variant(s).
|Mutations||S/T E/G L/I R/K Y/H|
|Epitope Location||S2T E4G L5I R6K Y9H|
|HXB2 Location||S72T E74G L75I R76K Y79H|
|Mutation Type||OV: observed variant|
|Note||Cross-clade T cell responses are frequently induced in individuals infected with different HIV-1 clades. There was an inverse correlation between the height of responses and epitope sequence divergence. For Gag epitopes, the magnitude of the response was directly linked to the homology between HLA anchor residues.|
Geels2005 Mark J. Geels, Sheri A. Dubey, Kiersten Anderson, Elly Baan, Margreet Bakker, Georgios Pollakis, William A. Paxton, John W. Shiver, and Jaap Goudsmit. Broad Cross-Clade T-Cell Responses to Gag in Individuals Infected with Human Immunodeficiency Virus Type 1 Non-B Clades (A to G): Importance of HLA Anchor Residue Conservation. J. Virol., 79(17):11247-11258, Sep 2005. PubMed ID: 16103177. Show all entries for this paper.