HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


Found 1 matching record:

Displaying record number 53683

HXB2 Location  Gag(24-31)   Gag Epitope Map
View variants at this location
Epitope GGKKKYKL   Epitope Alignment
GGKKKYKm   observed variant
Species (MHC/HLA human(B8)

Variant Details

Showing all: 1 variant(s).

Variant ID.  327
Epitope Seq.  GGKKKYKL
Variant Seq.  GGKKKYKm
Mutations L/M
Epitope Location L8M
HXB2 Location L31M
Mutation Type OV: observed variant
Note Cross-clade T cell responses are frequently induced in individuals infected with different HIV-1 clades. There was an inverse correlation between the height of responses and epitope sequence divergence. For Gag epitopes, the magnitude of the response was directly linked to the homology between HLA anchor residues.


Geels2005 Mark J. Geels, Sheri A. Dubey, Kiersten Anderson, Elly Baan, Margreet Bakker, Georgios Pollakis, William A. Paxton, John W. Shiver, and Jaap Goudsmit. Broad Cross-Clade T-Cell Responses to Gag in Individuals Infected with Human Immunodeficiency Virus Type 1 Non-B Clades (A to G): Importance of HLA Anchor Residue Conservation. J. Virol., 79(17):11247-11258, Sep 2005. PubMed ID: 16103177. Show all entries for this paper.

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