HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


Found 1 matching record:

Displaying record number 59074

HXB2 Location  Gag(203-212)   Gag Epitope Map
View variants at this location
Epitope ETINEEAAEW   Epitope Alignment
ETINdEAAEW   diminished response
Species (MHC/HLA human(A*25:01)

Variant Details

Showing all: 1 variant(s).

Variant ID.  3247
Epitope Seq.  ETINEEAAEW
Variant Seq.  ETINdEAAEW
Mutations E/D
Epitope Location E5D
HXB2 Location E207D
Mutation Type DR: diminished response
Epitope Subtype B
Variant Subtype B
Method Peptide titration
Note Ratio of EliSpot peptide titration of this mutant to original epitope EC50ratio = 27, suggesting partial escape.


Liu2007a Yi Liu, John McNevin, Hong Zhao, Denis M. Tebit, Ryan M. Troyer, Matthew McSweyn, Ananta K. Ghosh, Daniel Shriner, Eric J. Arts, M. Juliana McElrath, and James I. Mullins. Evolution of Human Immunodeficiency Virus Type 1 Cytotoxic T-Lymphocyte Epitopes: Fitness-Balanced Escape. J. Virol., 81(22):12179-12188, Nov 2007. PubMed ID: 17728222. Show all entries for this paper.

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