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Found 1 matching record:

Displaying record number 85

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLYNTVATL   Epitope Alignment
Variants
SLYNTiAvL   diminished HLA binding or increased off-rate
Epitope Name SL9
Species (MHC/HLA human(A2)

Variant Details

Showing 1 of 11 variants.


Variant ID.  3243
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTiAvL
Mutations V/I T/V
Epitope Location V6I T8V
HXB2 Location V82I T84V
Mutation Type DHB: diminished HLA binding or increased off-rate
Method Chromium-release assay, HLA binding
Note 6I, 8V variant peptide SLYNTiAvL was found in patient 9300868 and bound HLA-A*02 at a relative binding of 58% compared to SL9 index peptide. Lysis occurs in both CTL lines 9300868 and 003.

References

Sewell1997 A. K. Sewell, G. C. Harcourt, P. J. Goulder, D. A. Price, and R. E. Phillips. Antagonism of Cytotoxic T Lymphocyte-Mediated Lysis by Natural HIV-1 Altered Peptide Ligands Requires Simultaneous Presentation of Agonist and Antagonist Peptides. Eur. J. Immunol., 27:2323-2329, 1997. PubMed ID: 9341776. Show all entries for this paper.


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