HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


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Displaying record number 85

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLYNTVATL   Epitope Alignment
SLfNTiAvL   diminished HLA binding or increased off-rate
Epitope Name SL9
Species (MHC/HLA human(A2)

Variant Details

Showing 1 of 11 variants.

Variant ID.  3241
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNTiAvL
Mutations Y/F V/I T/V
Epitope Location Y3F V6I T8V
HXB2 Location Y79F V82I T84V
Mutation Type DHB: diminished HLA binding or increased off-rate
Method Chromium-release assay, HLA binding
Note 3F, 6I, 8V variant peptide SLfNTiAvL bound HLA-A*02 at a relative binding of 48% compared to SL9 index peptide. Lysis is abrogated in CTL line 9300868 but occurs in CTL line 003.


Sewell1997 A. K. Sewell, G. C. Harcourt, P. J. Goulder, D. A. Price, and R. E. Phillips. Antagonism of Cytotoxic T Lymphocyte-Mediated Lysis by Natural HIV-1 Altered Peptide Ligands Requires Simultaneous Presentation of Agonist and Antagonist Peptides. Eur. J. Immunol., 27:2323-2329, 1997. PubMed ID: 9341776. Show all entries for this paper.

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