HIV molecular immunology database
Found 1 matching record:
|HXB2 Location||Gag(77-85)|| Gag Epitope Map
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Showing 1 of 11 variants.
|Epitope Location||Y3F T5A|
|HXB2 Location||Y79F T81A|
|Mutation Type||DHB: diminished HLA binding or increased off-rate|
|Method||Chromium-release assay, HLA binding|
|Note||3F, 5A variant peptide SLfNaVATL bound HLA-A*02 at a relative binding of 80% compared to SL9 index peptide, but is a strict antagonist. Lysis is abrogated in CTL lines 9300868 and 003 at all concentrations tested.|
Sewell1997 A. K. Sewell, G. C. Harcourt, P. J. Goulder, D. A. Price, and R. E. Phillips. Antagonism of Cytotoxic T Lymphocyte-Mediated Lysis by Natural HIV-1 Altered Peptide Ligands Requires Simultaneous Presentation of Agonist and Antagonist Peptides. Eur. J. Immunol., 27:2323-2329, 1997. PubMed ID: 9341776. Show all entries for this paper.