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Search the Epitope Variant and Escape Mutation Database


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Displaying record number 85

HXB2 Location  Gag(77-85)   Gag Epitope Map
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Epitope SLYNTVATL   Epitope Alignment
SLfNaVATL   diminished HLA binding or increased off-rate
Epitope Name SL9
Species (MHC/HLA human(A2)

Variant Details

Showing 1 of 11 variants.

Variant ID.  3240
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNaVATL
Mutations Y/F T/A
Epitope Location Y3F T5A
HXB2 Location Y79F T81A
Mutation Type DHB: diminished HLA binding or increased off-rate
Method Chromium-release assay, HLA binding
Note 3F, 5A variant peptide SLfNaVATL bound HLA-A*02 at a relative binding of 80% compared to SL9 index peptide, but is a strict antagonist. Lysis is abrogated in CTL lines 9300868 and 003 at all concentrations tested.


Sewell1997 A. K. Sewell, G. C. Harcourt, P. J. Goulder, D. A. Price, and R. E. Phillips. Antagonism of Cytotoxic T Lymphocyte-Mediated Lysis by Natural HIV-1 Altered Peptide Ligands Requires Simultaneous Presentation of Agonist and Antagonist Peptides. Eur. J. Immunol., 27:2323-2329, 1997. PubMed ID: 9341776. Show all entries for this paper.

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