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Displaying record number 85

HXB2 Location Gag(77-85) Gag Epitope Map
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Epitope

SLYNTVATL

Epitope Alignment

Variants

SLYNTiATL observed variant

Epitope Name SL9

Species (MHC/HLA) human(A2)

Variant Details

Showing 1 of 11 variants.

Variant ID.	`3239`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYNTiATL`
Mutations	V/I
Epitope Location	V6I
HXB2 Location	V82I
Mutation Type	OV: observed variant
Method	Chromium-release assay, HLA binding
Note	Natural 6I variant SLYNTiATL, was found in patients 9300868 and 241. Variant peptide bound HLA-A*02 at a relative binding of 114% compared to SL9 index peptide. Lysis of CTL lines occurs at all concentrations of peptide tested.

References

Sewell1997 A. K. Sewell, G. C. Harcourt, P. J. Goulder, D. A. Price, and R. E. Phillips. Antagonism of Cytotoxic T Lymphocyte-Mediated Lysis by Natural HIV-1 Altered Peptide Ligands Requires Simultaneous Presentation of Agonist and Antagonist Peptides. Eur. J. Immunol., 27:2323-2329, 1997. PubMed ID: 9341776. Show all entries for this paper.