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Displaying record number 85

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLYNTVATL   Epitope Alignment
Variants
SLYNTiATL   observed variant
Epitope Name SL9
Species (MHC/HLA human(A2)

Variant Details

Showing 1 of 11 variants.


Variant ID.  3239
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTiATL
Mutations V/I
Epitope Location V6I
HXB2 Location V82I
Mutation Type OV: observed variant
Method Chromium-release assay, HLA binding
Note Natural 6I variant SLYNTiATL, was found in patients 9300868 and 241. Variant peptide bound HLA-A*02 at a relative binding of 114% compared to SL9 index peptide. Lysis of CTL lines occurs at all concentrations of peptide tested.

References

Sewell1997 A. K. Sewell, G. C. Harcourt, P. J. Goulder, D. A. Price, and R. E. Phillips. Antagonism of Cytotoxic T Lymphocyte-Mediated Lysis by Natural HIV-1 Altered Peptide Ligands Requires Simultaneous Presentation of Agonist and Antagonist Peptides. Eur. J. Immunol., 27:2323-2329, 1997. PubMed ID: 9341776. Show all entries for this paper.


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