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HIV Molecular Immunology Database

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Found 1 matching record:

Displaying record number 85

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLYNTVATL   Epitope Alignment
Variants
SLcNTVATL   diminished HLA binding or increased off-rate
Epitope Name SL9
Species (MHC/HLA human(A2)

Variant Details

Showing 1 of 11 variants.


Variant ID.  3238
Epitope Seq.  SLYNTVATL
Variant Seq.  SLcNTVATL
Mutations Y/C
Epitope Location Y3C
HXB2 Location Y79C
Mutation Type DHB: diminished HLA binding or increased off-rate
Method Chromium-release assay, HLA binding
Note Variant peptide SLcNTVATL bound HLA-A*02 at a relative binding of 86% compared to SL9 index peptide. Lysis is abrogated in CTL lines 9300868 and 003 at lower concentrations.

References

Sewell1997 A. K. Sewell, G. C. Harcourt, P. J. Goulder, D. A. Price, and R. E. Phillips. Antagonism of Cytotoxic T Lymphocyte-Mediated Lysis by Natural HIV-1 Altered Peptide Ligands Requires Simultaneous Presentation of Agonist and Antagonist Peptides. Eur. J. Immunol., 27:2323-2329, 1997. PubMed ID: 9341776. Show all entries for this paper.


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