HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


Found 1 matching record:

Displaying record number 85

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLYNTVATL   Epitope Alignment
SLlNTVATL   diminished HLA binding or increased off-rate
Epitope Name SL9
Species (MHC/HLA human(A2)

Variant Details

Showing 1 of 11 variants.

Variant ID.  3237
Epitope Seq.  SLYNTVATL
Variant Seq.  SLlNTVATL
Mutations Y/L
Epitope Location Y3L
HXB2 Location Y79L
Mutation Type DHB: diminished HLA binding or increased off-rate
Method Chromium-release assay, HLA binding
Note Natural 3L variant SLlNTVATL, was found in patients 003 and 008. Variant peptide bound HLA-A*02 at a relative binding of 76% compared to SL9 index peptide. Lysis is abrogated in CTL lines 9300868 and 003 at lower concentrations.


Sewell1997 A. K. Sewell, G. C. Harcourt, P. J. Goulder, D. A. Price, and R. E. Phillips. Antagonism of Cytotoxic T Lymphocyte-Mediated Lysis by Natural HIV-1 Altered Peptide Ligands Requires Simultaneous Presentation of Agonist and Antagonist Peptides. Eur. J. Immunol., 27:2323-2329, 1997. PubMed ID: 9341776. Show all entries for this paper.

Questions or comments? Contact us at
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health