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Displaying record number 85

HXB2 Location Gag(77-85) Gag Epitope Map
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Epitope

SLYNTVATL

Epitope Alignment

Variants

SLfNTVAvL diminished HLA binding or increased off-rate

Epitope Name SL9

Species (MHC/HLA) human(A2)

Variant Details

Showing 1 of 11 variants.

Variant ID.	`3234`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLfNTVAvL`
Mutations	Y/F T/V
Epitope Location	Y3F T8V
HXB2 Location	Y79F T84V
Mutation Type	DHB: diminished HLA binding or increased off-rate
Method	Chromium-release assay, HLA binding
Note	Natural 3F,8V variant SLfNTVAvL, was found in patients 001 and 008. Variant peptide bound HLA-A*02 at a relative binding of 72% compared to SL9 index peptide. Lysis is abrogated in CTL line 9300868 at lower concentrations, but occurs in CTL line 003.

References

Sewell1997 A. K. Sewell, G. C. Harcourt, P. J. Goulder, D. A. Price, and R. E. Phillips. Antagonism of Cytotoxic T Lymphocyte-Mediated Lysis by Natural HIV-1 Altered Peptide Ligands Requires Simultaneous Presentation of Agonist and Antagonist Peptides. Eur. J. Immunol., 27:2323-2329, 1997. PubMed ID: 9341776. Show all entries for this paper.