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Found 1 matching record:

Displaying record number 59012

HXB2 Location  Gag(22-30)   Gag Epitope Map
View variants at this location
Epitope RPGGKKHYM   Epitope Alignment
Variants
RPGGKKkYk   subtype-specific non-susceptible form
Epitope Name RM9-p17
Species (MHC/HLA human(B*07:02)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3219
Epitope Seq.  RPGGKKHYM
Variant Seq.  RPGGKKkYk
Mutations H/K M/K
Epitope Location H7K M9K
HXB2 Location H28K M30K
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype C
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, HLA binding
Note Epitope RK9, RPGGKKkYk, the B-clade consensus epitope differs at H7K and M9K, and is not recognized by HLA-B*0702. RK9 is unstable in complex with HLA-B*0702; and its binding affinity is Kd = >20,000 nM. RK9 is contained within OLP3, EKIRLRPGGKKkYkLKHI.

References

Kloverpris2014 Henrik N. Kløverpris, Emily Adland, Madoka Koyanagi, Anette Stryhn, Mikkel Harndahl, Philippa C. Matthews, Roger Shapiro, Bruce D. Walker, Thumbi Ndung'u, Christian Brander, Masafumi Takiguchi, Søren Buus, and Philip Goulder. HIV Subtype Influences HLA-B*07:02-Associated HIV Disease Outcome. AIDS Res. Hum. Retroviruses, 30(5):468-475, May 2014. PubMed ID: 24010680. Show all entries for this paper.


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