HIV molecular immunology database

 

Search the Epitope Variant and Escape Mutation Database

Help


Found 1 matching record:

Displaying record number 58813

HXB2 Location  Gag(180-188)   Gag Epitope Map
View variants at this location
Epitope TPQDLNTML   Epitope Alignment
Variants
TPQDLNTMf{...q...v...i}   observed variant
Epitope Name TL9
Species (MHC/HLA human(B*39:10, B*81:01)

Variant Details

Showing 1 of 17 variants.


Variant ID.  3171
Epitope Seq.  TPQDLNTML{...H...I...M}
Variant Seq.  TPQDLNTMf{...q...v...i}
Mutations H/Q I/V M/I L/F
Epitope Location H31Q I35V M62I L9F
HXB2 Location H219Q I223V M250I L188F
Mutation Type OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Sequence
Note A mutation within TL9, L188F had developed by 76 weeks post-infection, and putative compensatory mutations H219Q, I223V and M250I had also developed by then in a B*4201, Cw*0802-positive subject

References

Ntale2012 R. S. Ntale, D. R. Chopera, N. K. Ngandu, D. Assis de Rosa, L. Zembe, H. Gamieldien, M. Mlotshwa, L. Werner, Z. Woodman, K. Mlisana, S. Abdool Karim, C. M. Gray, C. Williamson, and CAPRISA 002 Study Team. Temporal Association of HLA-B*81:01- and HLA-B*39:10-Mediated HIV-1 p24 Sequence Evolution with Disease Progression. J. Virol., 86(22):12013-12024, Nov 2012. PubMed ID: 22933291. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health