HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | Gag(180-188) | Gag Epitope Map
View variants at this location |
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| Epitope |
TPQDLNTML
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Epitope Alignment | ||||
| Variants |
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| Epitope Name | TL9 | |||||
| Species (MHC/HLA) | human(B*39:10, B*81:01) | |||||
Showing 1 of 17 variants.
| Variant ID. | 3169 |
|---|---|
| Epitope Seq. | TPQDLNTML{...A} |
| Variant Seq. | TPsDLNsML{...t} |
| Mutations | Q/S A/T T/S |
| Epitope Location | Q3S A+60T T7S |
| HXB2 Location | Q182S A248T T186S |
| Mutation Type | OV: observed variant |
| Epitope Subtype | C |
| Variant Subtype | C |
| Method | Sequence |
| Note | Mutations within TL9, Q182S and T186S had developed by 110 weeks post-infection, as well as a putative compensatory mutation at A248T in a B*8101-positive subject [Donor HLA = A*3009, A*4301, B*5802, B*8101, Cw*0401, Cw*0401; this subject was a controller for the first 18-24 months and thereafter became a progressor]. |
Ntale2012 R. S. Ntale, D. R. Chopera, N. K. Ngandu, D. Assis de Rosa, L. Zembe, H. Gamieldien, M. Mlotshwa, L. Werner, Z. Woodman, K. Mlisana, S. Abdool Karim, C. M. Gray, C. Williamson, and CAPRISA 002 Study Team. Temporal Association of HLA-B*81:01- and HLA-B*39:10-Mediated HIV-1 p24 Sequence Evolution with Disease Progression. J. Virol., 86(22):12013-12024, Nov 2012. PubMed ID: 22933291. Show all entries for this paper.