HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


Found 1 matching record:

Displaying record number 58813

HXB2 Location  Gag(180-188)   Gag Epitope Map
View variants at this location
Epitope TPQDLNTML   Epitope Alignment
TPhDLNTML{...i}   observed variant
Epitope Name TL9
Species (MHC/HLA human(B*39:10, B*81:01)

Variant Details

Showing 1 of 17 variants.

Variant ID.  3164
Epitope Seq.  TPQDLNTML{...M}
Variant Seq.  TPhDLNTML{...i}
Mutations Q/H M/I
Epitope Location Q3H M+62I
HXB2 Location Q182H M250I
Mutation Type OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Sequence
Note A mutation within TL9, Q182H, had developed by 50 weeks post-infection, and a putative compensatory mutation, M250I, had also developed by then in a B*8101-positive subject [Donor HLA = A*3009, A*4301, B*5802, B*8101, Cw*0401, Cw*0401; this subject was a controller for the first 18-24 months and thereafter became a progressor].


Ntale2012 R. S. Ntale, D. R. Chopera, N. K. Ngandu, D. Assis de Rosa, L. Zembe, H. Gamieldien, M. Mlotshwa, L. Werner, Z. Woodman, K. Mlisana, S. Abdool Karim, C. M. Gray, C. Williamson, and CAPRISA 002 Study Team. Temporal Association of HLA-B*81:01- and HLA-B*39:10-Mediated HIV-1 p24 Sequence Evolution with Disease Progression. J. Virol., 86(22):12013-12024, Nov 2012. PubMed ID: 22933291. Show all entries for this paper.

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