HIV molecular immunology database
Found 1 matching record:
|HXB2 Location||Gag(180-188)|| Gag Epitope Map
View variants at this location
|Species (MHC/HLA)||human(B*39:10, B*81:01)|
Showing 1 of 17 variants.
|Mutations||E/D Q/S I/V T/S|
|Epitope Location||E-3D Q3S I+35V T7S|
|HXB2 Location||E177D Q182S I223V T186S|
|Mutation Type||OV: observed variant|
|Note||Mutations within TL9, E177D, Q182S had developed by 108 weeks post-infection, and putative compensatory mutations I223V had also developed by then in a B*8101-positive subject [Donor HLA = A*3001, A*3303, B*5301, B*8101, Cw*0401, Cw*0401; after an initial 18-24 months of control, this subject had an increased VL and decreased CD4+ T cell counts]. The very same set of mutations developed in a B*3910-positive subject too, by 9 weeks post-infection [Donor HLA = A*3001, A*4301, B*3901, B*4202, Cw*1203, Cw*1701; a controller of infection]|
Ntale2012 R. S. Ntale, D. R. Chopera, N. K. Ngandu, D. Assis de Rosa, L. Zembe, H. Gamieldien, M. Mlotshwa, L. Werner, Z. Woodman, K. Mlisana, S. Abdool Karim, C. M. Gray, C. Williamson, and CAPRISA 002 Study Team. Temporal Association of HLA-B*81:01- and HLA-B*39:10-Mediated HIV-1 p24 Sequence Evolution with Disease Progression. J. Virol., 86(22):12013-12024, Nov 2012. PubMed ID: 22933291. Show all entries for this paper.