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Found 1 matching record:

Displaying record number 58813

HXB2 Location  Gag(180-188)   Gag Epitope Map
View variants at this location
Epitope TPQDLNTML   Epitope Alignment
Variants
TPtDLNTML{...h...t}   observed variant
Epitope Name TL9
Species (MHC/HLA human(B*39:10, B*81:01)

Variant Details

Showing 1 of 17 variants.


Variant ID.  3155
Epitope Seq.  TPQDLNTML{...I...A}
Variant Seq.  TPtDLNTML{...h...t}
Mutations Q/T I/H A/T
Epitope Location Q3T I+35H A+60T
HXB2 Location Q182T I223H A248T
Mutation Type OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Sequence
Note A mutation within TL9, Q182T had developed by 2 weeks post-infection , and putative compensatory mutations I223H and A248T had also developed by then in a B*8101-positive subject [Donor HLA = A*2601, A*8001, B*1801, B*8101, Cw*0202, Cw*0401; relatively high VL with CD4+ cell count increasing between years 3-4 post-infection]

References

Ntale2012 R. S. Ntale, D. R. Chopera, N. K. Ngandu, D. Assis de Rosa, L. Zembe, H. Gamieldien, M. Mlotshwa, L. Werner, Z. Woodman, K. Mlisana, S. Abdool Karim, C. M. Gray, C. Williamson, and CAPRISA 002 Study Team. Temporal Association of HLA-B*81:01- and HLA-B*39:10-Mediated HIV-1 p24 Sequence Evolution with Disease Progression. J. Virol., 86(22):12013-12024, Nov 2012. PubMed ID: 22933291. Show all entries for this paper.


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