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Displaying record number 58783

HXB2 Location Gag(209-218) Gag Epitope Map
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Epitope

AAEWDRLHPV

Epitope Alignment

Variants

AAEWDRxHP- HLA association; diminished HLA binding or increased off-rate

Epitope Name p24Gag209-218

Species (MHC/HLA) human

Variant Details

Showing 1 of 9 variants.

Variant ID.	`3154`
Epitope Seq.	`AAEWDRLHPV`
Variant Seq.	`AAEWDRxHP-`
Mutations	V/- L/X
Epitope Location	V10- L7X
HXB2 Location	V218- L215X
Mutation Type	A: HLA association DHB: diminished HLA binding or increased off-rate
Epitope Subtype	B
Variant Subtype	B
Method	HLA binding
Note	All sequences with mutations at position 7 and without the C-terminal Valine were unable to bind Cw*0102.

References

Fadda2012 Lena Fadda, Christian Körner, Swati Kumar, Nienke H. van Teijlingen, Alicja Piechocka-Trocha, Mary Carrington, and Marcus Altfeld. HLA-Cw*0102-Restricted HIV-1 p24 Epitope Variants Can Modulate the Binding of the Inhibitory KIR2DL2 Receptor and Primary NK Cell Function. PLoS Pathog., 8(7):e1002805, 2012. PubMed ID: 22807681. Show all entries for this paper.