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Found 1 matching record:

Displaying record number 58783

HXB2 Location  Gag(209-218)   Gag Epitope Map
View variants at this location
Epitope AAEWDRLHPV   Epitope Alignment
Variants
-AEWDRxHPV   HLA association; diminished HLA binding or increased off-rate
Epitope Name p24Gag209-218
Species (MHC/HLA human

Variant Details

Showing 1 of 9 variants.


Variant ID.  3153
Epitope Seq.  AAEWDRLHPV
Variant Seq.  -AEWDRxHPV
Mutations A/- L/X
Epitope Location A1- L7X
HXB2 Location A209- L215X
Mutation Type A: HLA association
DHB: diminished HLA binding or increased off-rate
Epitope Subtype B
Variant Subtype B
Method HLA binding
Note All sequences with mutations at position 7 and without the N-terminal Alanine were able to bind Cw*0102, but at reduced levels.

References

Fadda2012 Lena Fadda, Christian Körner, Swati Kumar, Nienke H. van Teijlingen, Alicja Piechocka-Trocha, Mary Carrington, and Marcus Altfeld. HLA-Cw*0102-Restricted HIV-1 p24 Epitope Variants Can Modulate the Binding of the Inhibitory KIR2DL2 Receptor and Primary NK Cell Function. PLoS Pathog., 8(7):e1002805, 2012. PubMed ID: 22807681. Show all entries for this paper.


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