HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


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Displaying record number 58783

HXB2 Location  Gag(209-218)   Gag Epitope Map
View variants at this location
Epitope AAEWDRLHPV   Epitope Alignment
AAEWDRmHPV   HLA association; diminished HLA binding or increased off-rate
Epitope Name p24Gag209-218
Species (MHC/HLA human

Variant Details

Showing 1 of 9 variants.

Variant ID.  3146
Epitope Seq.  AAEWDRLHPV
Variant Seq.  AAEWDRmHPV
Mutations L/M
Epitope Location L7M
HXB2 Location L215M
Mutation Type A: HLA association
DHB: diminished HLA binding or increased off-rate
Epitope Subtype B
Variant Subtype B
Method HLA binding
Note Gag209-218-M, AAEWDRmHPV, binds HLA-Cw*0102 but at a decreased level. 2.9% sequences carried this variation.


Fadda2012 Lena Fadda, Christian Körner, Swati Kumar, Nienke H. van Teijlingen, Alicja Piechocka-Trocha, Mary Carrington, and Marcus Altfeld. HLA-Cw*0102-Restricted HIV-1 p24 Epitope Variants Can Modulate the Binding of the Inhibitory KIR2DL2 Receptor and Primary NK Cell Function. PLoS Pathog., 8(7):e1002805, 2012. PubMed ID: 22807681. Show all entries for this paper.

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