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Found 1 matching record:

Displaying record number 58700

HXB2 Location  Gag(22-30)   Gag Epitope Map
View variants at this location
Epitope RPGGKKHYM   Epitope Alignment
Variants
RPGGKKrYM   escape documented in this paper
Epitope Name p17-RM9
Species (MHC/HLA human(B*42:01, B*42:02)

Variant Details

Showing 1 of 3 variants.


Variant ID.  3110
Epitope Seq.  RPGGKKHYM
Variant Seq.  RPGGKKrYM
Mutations H/R
Epitope Location H7R
HXB2 Location H28R
Mutation Type E: escape documented in this paper
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note p17-RM9 mutation, RPGGKKrYM, is selected in 13% HLA-B*4201 (8% have wt RM9), 10% HLA-B*4202 (31% have wt RM9) and 8% on-HLA-B*42 (46% have wt RM9) subjects. The authors designate this variant as an escape when presented by HLAs-B*4201 and -B*4202.

References

Kloverpris2012a Henrik N. Kløverpris, Mikkel Harndahl, Alasdair J. Leslie, Jonathan M. Carlson, Nasreen Ismail, Mary van der Stok, Kuan-Hsiang Gary Huang, Fabian Chen, Lynn Riddell, Dewald Steyn, Dominique Goedhals, Cloete van Vuuren, John Frater, Bruce D. Walker, Mary Carrington, Thumbi Ndung'u, Søren Buus, and Philip Goulder. HIV Control through a Single Nucleotide on the HLA-B Locus. J. Virol., 86(21):11493-11500, Nov 2012. PubMed ID: 22896606. Show all entries for this paper.


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