HIV molecular immunology database
Found 1 matching record:
|HXB2 Location||Gag(168-175)|| Gag Epitope Map
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Showing all: 1 variant(s).
|Mutation Type||A: HLA association
DR: diminished response
E: escape documented in this paper
|Method||CD8 T-cell Elispot - IFNy, Intracellular cytokine staining|
|Note||C-mut VIPMtFAL was the result of an S173T substitution in Gag epitope VIPMSFAL (VL8). A peptide containing VIPMtFAL escape was less well recognized than wt VL8 as proved by testing for γ-IFN and TNF-α production with intracellular cytokine staining (ICS) of a VL8-specific CTL cell line and its HLA-Cw*0102-transfected APC.|
Blais2012 Marie-Eve Blais, Yonghong Zhang, Tim Rostron, Harry Griffin, Stephen Taylor, Keyi Xu, Huiping Yan, Hao Wu, Ian James, Mina John, Tao Dong, and Sarah L. Rowland-Jones. High Frequency of HIV Mutations Associated with HLA-C Suggests Enhanced HLA-C-Restricted CTL Selective Pressure Associated with an AIDS-Protective Polymorphism. J. Immunol., 188(9):4663-4670, 1 May 2012. PubMed ID: 22474021. Show all entries for this paper.