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HIV Molecular Immunology Database

Search the Epitope Variant and Escape Mutation Database

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Found 1 matching record:

Displaying record number 58688

HXB2 Location  Gag(240-249)   Gag Epitope Map
View variants at this location
Epitope TSTLQEQIAW   Epitope Alignment
Variants
TSxLQEQIAW   observed variant
Epitope Name TW10
Species (MHC/HLA human(B*57:02, B*57:03, B*58:01)

Variant Details

Showing 1 of 2 variants.


Variant ID.  3102
Epitope Seq.  TSTLQEQIAW
Variant Seq.  TSxLQEQIAW
Mutations T/X
Epitope Location T3X
HXB2 Location T242X
Mutation Type OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Sequence
Note Mutation TSxLQEQIAW was seen in >75% of both HLA-B*5703 and -B*5702 positive subjects, and in just under 75% of HLA-B*5801 carrying subjects.

References

Kloverpris2012 Henrik N. Kloverpris, Anette Stryhn, Mikkel Harndahl, Mary van der Stok, Rebecca P. Payne, Philippa C. Matthews, Fabian Chen, Lynn Riddell, Bruce D. Walker, Thumbi Ndung'u, Søren Buus, and Philip Goulder. HLA-B*57 Micropolymorphism Shapes HLA Allele-Specific Epitope Immunogenicity, Selection Pressure, and HIV Immune Control. J. Virol., 86(2):919-929, Jan 2012. PubMed ID: 22090105. Show all entries for this paper.


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