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Displaying record number 58674

HXB2 Location Gag(147-155) Gag Epitope Map
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Epitope

ISPRTLNAW

Epitope Alignment

Variants

xSPRTLNAW calculated escape

Epitope Name ISW9

Species (MHC/HLA) human(B*57:01, B*57:02, B*57:03, B*58:01)

Variant Details

Showing 1 of 2 variants.

Variant ID.	`3094`
Epitope Seq.	`ISPRTLNAW`
Variant Seq.	`xSPRTLNAW`
Mutations	I/X
Epitope Location	I2X
HXB2 Location	I148X
Mutation Type	CE: calculated escape
Epitope Subtype	C
Variant Subtype	C
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	ISW9 escapes at I147X, xSPRTLNAW, are seen in >75% of HLA-B5703 and -B5702 positive subjects.

References

Kloverpris2012 Henrik N. Kloverpris, Anette Stryhn, Mikkel Harndahl, Mary van der Stok, Rebecca P. Payne, Philippa C. Matthews, Fabian Chen, Lynn Riddell, Bruce D. Walker, Thumbi Ndung'u, Søren Buus, and Philip Goulder. HLA-B*57 Micropolymorphism Shapes HLA Allele-Specific Epitope Immunogenicity, Selection Pressure, and HIV Immune Control. J. Virol., 86(2):919-929, Jan 2012. PubMed ID: 22090105. Show all entries for this paper.