HIV molecular immunology database
Found 1 matching record:
HXB2 Location | Gag(162-172) | Gag Epitope Map
View variants at this location |
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Epitope |
KAFSPEVIPMF
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Epitope Alignment | ||||
Variants |
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Epitope Name | KF11 | |||||
Species (MHC/HLA) | human(B*57) |
Showing 1 of 7 variants.
Variant ID. | 3068 |
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Epitope Seq. | KAFSPEVIPMF |
Variant Seq. | KgFnPEVIPMF |
Mutations | A/G S/N |
Epitope Location | A2G S4N |
HXB2 Location | A163G S165N |
Mutation Type | A: HLA association E: escape documented in this paper NSF: non-susceptible form |
Method | CD8 T-cell Elispot - IFNy, Sequence |
Note | For mutation A163G, S165N CTL recognition of KgFnPEVIPMF was ablated. 14% of HLA-B*57-positive subjects, 6% of HLA-B*5801-positive subjects, and 5% of HLA-B*57/5801-negative subjects carried this variant. |
Leslie2005a Alasdair Leslie, Daniel Kavanagh, Isobella Honeyborne, Katja Pfafferott, Charles Edwards, Tilly Pillay, Louise Hilton, Christina Thobakgale, Danni Ramduth, Rika Draenert, Sylvie Le Gall, Graz Luzzi, Anne Edwards, Christian Brander, Andrew K. Sewell, Sarah Moore, James Mullins, Corey Moore, Simon Mallal, Nina Bhardwaj, Karina Yusim, Rodney Phillips, Paul Klenerman, Bette Korber, Photini Kiepiela, Bruce Walker, and Philip Goulder. Transmission and Accumulation of CTL Escape Variants Drive Negative Associations between HIV Polymorphisms and HLA. J. Exp. Med., 201(6):891-902, 21 Mar 2005. PubMed ID: 15781581. Show all entries for this paper.