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Displaying record number 53776

HXB2 Location Gag(162-172) Gag Epitope Map
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Epitope

KAFSPEVIPMF

Epitope Alignment

Variants

KnFSPEVIPMF HLA association; escape documented in this paper; non-susceptible form

Epitope Name KF11

Species (MHC/HLA) human(B*57)

Variant Details

Showing 1 of 7 variants.

Variant ID.	`3067`
Epitope Seq.	`KAFSPEVIPMF`
Variant Seq.	`KnFSPEVIPMF`
Mutations	A/N
Epitope Location	A2N
HXB2 Location	A163N
Mutation Type	A: HLA association E: escape documented in this paper NSF: non-susceptible form
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Variant KnFSPEVIPMF (A163N) did not elicit response in EliSpot assays. 8% of HLA-B57-positive subjects, 2% of HLA-B5801-positive subjects, and 1% of HLA-B&57/5801-negative subjects carried this variant.

References

Leslie2005a Alasdair Leslie, Daniel Kavanagh, Isobella Honeyborne, Katja Pfafferott, Charles Edwards, Tilly Pillay, Louise Hilton, Christina Thobakgale, Danni Ramduth, Rika Draenert, Sylvie Le Gall, Graz Luzzi, Anne Edwards, Christian Brander, Andrew K. Sewell, Sarah Moore, James Mullins, Corey Moore, Simon Mallal, Nina Bhardwaj, Karina Yusim, Rodney Phillips, Paul Klenerman, Bette Korber, Photini Kiepiela, Bruce Walker, and Philip Goulder. Transmission and Accumulation of CTL Escape Variants Drive Negative Associations between HIV Polymorphisms and HLA. J. Exp. Med., 201(6):891-902, 21 Mar 2005. PubMed ID: 15781581. Show all entries for this paper.