Found 1 matching record:
HXB2 Location | Gag(240-249) | Gag Epitope Map
View variants at this location |
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Epitope |
TSTLQEQIGW
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Epitope Alignment | ||||
Variants |
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Epitope Name | TW10 | |||||
Species (MHC/HLA) | human(B*57, B*58:01) |
Showing 1 of 27 variants.
Variant ID. | 2996 |
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Epitope Seq. | {I...}TSTLQEQIGW |
Variant Seq. | {v...}TSnLQEQIGW |
Mutations | I/V T/N |
Epitope Location | I-17V T3N |
HXB2 Location | I223V T242N |
Mutation Type | CM: compensatory mutation |
Epitope Subtype | B |
Variant Subtype | B |
Method | Sequence |
Note | I223V, compensatory mutation to T242N, is seen in increasing numbers in subjects with increasing plasma VL. This compensatory mutation alone cannot account for VL differences between HLA-B57/B*5801-positive persons. |
Miura2009a Toshiyuki Miura, Mark A. Brockman, Arne Schneidewind, Michael Lobritz, Florencia Pereyra, Almas Rathod, Brian L. Block, Zabrina L. Brumme, Chanson J. Brumme, Brett Baker, Alissa C. Rothchild, Bin Li, Alicja Trocha, Emily Cutrell, Nicole Frahm, Christian Brander, Ildiko Toth, Eric J. Arts, Todd M. Allen, and Bruce D. Walker. HLA-B57/B*5801 Human Immunodeficiency Virus Type 1 Elite Controllers Select for Rare Gag Variants Associated with Reduced Viral Replication Capacity and Strong Cytotoxic T-Lymphocyte Recognition. J Virol, 83(6):2743-2755, Mar 2009. PubMed ID: 19116253. Show all entries for this paper.
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