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HIV Molecular Immunology Database

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Found 1 matching record:

Displaying record number 57353

HXB2 Location  Gag(240-249)   Gag Epitope Map
View variants at this location
Epitope TSTLQEQIGW   Epitope Alignment
Variants
{v...}TSnLQEQIGW   compensatory mutation
Epitope Name TW10
Species (MHC/HLA human(B*57, B*58:01)

Variant Details

Showing 1 of 27 variants.


Variant ID.  2996
Epitope Seq.  {I...}TSTLQEQIGW
Variant Seq.  {v...}TSnLQEQIGW
Mutations I/V T/N
Epitope Location I-17V T3N
HXB2 Location I223V T242N
Mutation Type CM: compensatory mutation
Epitope Subtype B
Variant Subtype B
Method Sequence
Note I223V, compensatory mutation to T242N, is seen in increasing numbers in subjects with increasing plasma VL. This compensatory mutation alone cannot account for VL differences between HLA-B57/B*5801-positive persons.

References

Miura2009a Toshiyuki Miura, Mark A. Brockman, Arne Schneidewind, Michael Lobritz, Florencia Pereyra, Almas Rathod, Brian L. Block, Zabrina L. Brumme, Chanson J. Brumme, Brett Baker, Alissa C. Rothchild, Bin Li, Alicja Trocha, Emily Cutrell, Nicole Frahm, Christian Brander, Ildiko Toth, Eric J. Arts, Todd M. Allen, and Bruce D. Walker. HLA-B57/B*5801 Human Immunodeficiency Virus Type 1 Elite Controllers Select for Rare Gag Variants Associated with Reduced Viral Replication Capacity and Strong Cytotoxic T-Lymphocyte Recognition. J Virol, 83(6):2743-2755, Mar 2009. PubMed ID: 19116253. Show all entries for this paper.


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