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Displaying record number 57298

HXB2 Location Gag(77-86) Gag Epitope Map
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Epitope

SLYNTVATLY

Epitope Alignment

Variants

SLfNTiAvLY diminished HLA binding or increased off-rate; escape documented in this paper; susceptible form

Epitope Name SY10

Species (MHC/HLA) human(A*02)

Variant Details

Showing 1 of 7 variants.

Variant ID.	`2992`
Epitope Seq.	`SLYNTVATLY`
Variant Seq.	`SLfNTiAvLY`
Mutations	Y/F V/I T/V
Epitope Location	Y3F V6I T8V
HXB2 Location	Y79F V82I T84V
Mutation Type	DHB: diminished HLA binding or increased off-rate E: escape documented in this paper SF: susceptible form
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, HLA binding
Note	Variant SLfNTiAvLY could not bind HLA-A*02 in vitro; but did elicit ex-vivo EliSpot responses in at least 2 of 3 chronically-infected, untreated patients. The authors refer to all Y79F, V82I and T84V mutation-containing peptides as escapes.

References

Tenzer2009 Stefan Tenzer, Edmund Wee, Anne Burgevin, Guillaume Stewart-Jones, Lone Friis, Kasper Lamberth, Chih-hao Chang, Mikkel Harndahl, Mirjana Weimershaus, Jan Gerstoft, Nadja Akkad, Paul Klenerman, Lars Fugger, E. Yvonne Jones, Andrew J. McMichael, Søren Buus, Hansjörg Schild, Peter van Endert, and Astrid K. N. Iversen. Antigen Processing Influences HIV-Specific Cytotoxic T Lymphocyte Immunodominance. Nat. Immunol., 10(6):636-646, Jun 2009. PubMed ID: 19412183. Show all entries for this paper.