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Displaying record number 57298

HXB2 Location  Gag(77-86)   Gag Epitope Map
View variants at this location
Epitope SLYNTVATLY   Epitope Alignment
Variants
SLYNTiAvLY   diminished HLA binding or increased off-rate; escape documented in this paper; susceptible form
Epitope Name SY10
Species (MHC/HLA human(A*02)

Variant Details

Showing 1 of 7 variants.


Variant ID.  2990
Epitope Seq.  SLYNTVATLY
Variant Seq.  SLYNTiAvLY
Mutations V/I T/V
Epitope Location V6I T8V
HXB2 Location V82I T84V
Mutation Type DHB: diminished HLA binding or increased off-rate
E: escape documented in this paper
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, HLA binding
Note Variant SLYNTiAvLY could not bind HLA-A*02 in vivo; but did elicit ex-vivo EliSpot responses in at least 1 of 3 chronically-infected, untreated patients. The authors refer to all V82I and T84V mutation-containing peptides as escapes.

References

Tenzer2009 Stefan Tenzer, Edmund Wee, Anne Burgevin, Guillaume Stewart-Jones, Lone Friis, Kasper Lamberth, Chih-hao Chang, Mikkel Harndahl, Mirjana Weimershaus, Jan Gerstoft, Nadja Akkad, Paul Klenerman, Lars Fugger, E. Yvonne Jones, Andrew J. McMichael, Søren Buus, Hansjörg Schild, Peter van Endert, and Astrid K. N. Iversen. Antigen Processing Influences HIV-Specific Cytotoxic T Lymphocyte Immunodominance. Nat. Immunol., 10(6):636-646, Jun 2009. PubMed ID: 19412183. Show all entries for this paper.


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