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Displaying record number 57300

HXB2 Location Gag(76-86) Gag Epitope Map
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Epitope

RSLYNTVATLY

Epitope Alignment

Variants

kSLYNTiATLY diminished response; escape documented in this paper

Epitope Name RY11

Species (MHC/HLA) human(A*02:01, A*30:02)

Variant Details

Showing 1 of 15 variants.

Variant ID.	`2982`
Epitope Seq.	`RSLYNTVATLY`
Variant Seq.	`kSLYNTiATLY`
Mutations	R/K V/I
Epitope Location	R1K V7I
HXB2 Location	R76K V82I
Mutation Type	DR: diminished response E: escape documented in this paper
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, HLA binding
Note	Variant kSLYNTiATLY had an increase in binding to HLA-A*02 in vitro; but it showed a significant decrease in EliSpot response in 1 chronically-infected, untreated patient; abrogation of CTL responses in the second patient; and no change in the third when compared to wt RY11. The authors designate V82I mutation-containing peptides to be escapes.

References

Tenzer2009 Stefan Tenzer, Edmund Wee, Anne Burgevin, Guillaume Stewart-Jones, Lone Friis, Kasper Lamberth, Chih-hao Chang, Mikkel Harndahl, Mirjana Weimershaus, Jan Gerstoft, Nadja Akkad, Paul Klenerman, Lars Fugger, E. Yvonne Jones, Andrew J. McMichael, Søren Buus, Hansjörg Schild, Peter van Endert, and Astrid K. N. Iversen. Antigen Processing Influences HIV-Specific Cytotoxic T Lymphocyte Immunodominance. Nat. Immunol., 10(6):636-646, Jun 2009. PubMed ID: 19412183. Show all entries for this paper.