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Displaying record number 57300

HXB2 Location  Gag(76-86)   Gag Epitope Map
View variants at this location
Epitope RSLYNTVATLY   Epitope Alignment
Variants
RSLfNTVAvLY   diminished HLA binding or increased off-rate; diminished response; escape documented in this paper
Epitope Name RY11
Species (MHC/HLA human(A*02:01, A*30:02)

Variant Details

Showing 1 of 15 variants.


Variant ID.  2978
Epitope Seq.  RSLYNTVATLY
Variant Seq.  RSLfNTVAvLY
Mutations Y/F T/V
Epitope Location Y4F T9V
HXB2 Location Y79F T84V
Mutation Type DHB: diminished HLA binding or increased off-rate
DR: diminished response
E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, HLA binding
Note Variant RSLfNTVAvLY did not bind to HLA-A*02 in vitro, and it showed a significant decrease in ex-vivo EliSpot response in 1 chronically-infected, untreated patient; abrogation of CTL response in another such patient; with no changes in the third patient when compared to wt RY11. The authors designate Y79F and T84V mutation-containing peptides to be escapes.

References

Tenzer2009 Stefan Tenzer, Edmund Wee, Anne Burgevin, Guillaume Stewart-Jones, Lone Friis, Kasper Lamberth, Chih-hao Chang, Mikkel Harndahl, Mirjana Weimershaus, Jan Gerstoft, Nadja Akkad, Paul Klenerman, Lars Fugger, E. Yvonne Jones, Andrew J. McMichael, Søren Buus, Hansjörg Schild, Peter van Endert, and Astrid K. N. Iversen. Antigen Processing Influences HIV-Specific Cytotoxic T Lymphocyte Immunodominance. Nat. Immunol., 10(6):636-646, Jun 2009. PubMed ID: 19412183. Show all entries for this paper.


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