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Displaying record number 57300

HXB2 Location Gag(76-86) Gag Epitope Map
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Epitope

RSLYNTVATLY

Epitope Alignment

Variants

RSLYNTVAvLY diminished response; escape documented in this paper

Epitope Name RY11

Species (MHC/HLA) human(A*02:01, A*30:02)

Variant Details

Showing 1 of 15 variants.

Variant ID.	`2974`
Epitope Seq.	`RSLYNTVATLY`
Variant Seq.	`RSLYNTVAvLY`
Mutations	T/V
Epitope Location	T9V
HXB2 Location	T84V
Mutation Type	DR: diminished response E: escape documented in this paper
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, HLA binding
Note	Variant RSLYNTVAvLY bound at the same Kd to HLA-A*02 as to the WT sequence, but EliSpot response in 2/3 chronically-infected, untreated patients was abolished. Slightly diminished response was seen in one patient. The authors designate T84V mutation-containing peptides as escapes.

References

Tenzer2009 Stefan Tenzer, Edmund Wee, Anne Burgevin, Guillaume Stewart-Jones, Lone Friis, Kasper Lamberth, Chih-hao Chang, Mikkel Harndahl, Mirjana Weimershaus, Jan Gerstoft, Nadja Akkad, Paul Klenerman, Lars Fugger, E. Yvonne Jones, Andrew J. McMichael, Søren Buus, Hansjörg Schild, Peter van Endert, and Astrid K. N. Iversen. Antigen Processing Influences HIV-Specific Cytotoxic T Lymphocyte Immunodominance. Nat. Immunol., 10(6):636-646, Jun 2009. PubMed ID: 19412183. Show all entries for this paper.