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Displaying record number 57182

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLYNTVATL   Epitope Alignment
Variants
{k}SLfNTiAvL   literature escape
Epitope Name SL9
Species (MHC/HLA human(A*02:01)

Variant Details

Showing 1 of 9 variants.


Variant ID.  2966
Epitope Seq.  {R}SLYNTVATL
Variant Seq.  {k}SLfNTiAvL
Mutations -/K Y/F V/I T/V
Epitope Location -1K Y4F V7I T9V
HXB2 Location -77K Y80F V83I T85V
Mutation Type LE: literature escape
Epitope Subtype B
Variant Subtype B
Method Sequence
Note CTL selection at TCR contact residues is predicted to drive {k}SLfNTVAvL (SL9-KFV) or {k}SLfNTiATL(SL9-KFI) or {R}SLFNTiAvL(SL9-IV) to {k}SLfNTiAvL (SL9-KFIV), reversion to SL9-KFV is predicted to result from selection for optimal viral growth.

References

Tenzer2009 Stefan Tenzer, Edmund Wee, Anne Burgevin, Guillaume Stewart-Jones, Lone Friis, Kasper Lamberth, Chih-hao Chang, Mikkel Harndahl, Mirjana Weimershaus, Jan Gerstoft, Nadja Akkad, Paul Klenerman, Lars Fugger, E. Yvonne Jones, Andrew J. McMichael, Søren Buus, Hansjörg Schild, Peter van Endert, and Astrid K. N. Iversen. Antigen Processing Influences HIV-Specific Cytotoxic T Lymphocyte Immunodominance. Nat. Immunol., 10(6):636-646, Jun 2009. PubMed ID: 19412183. Show all entries for this paper.


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