HIV molecular immunology database

 

Search the Epitope Variant and Escape Mutation Database

Help


Found 1 matching record:

Displaying record number 58384

HXB2 Location  Gag(58-72)   Gag Epitope Map
View variants at this location
Epitope KQIMKQLQPALQTGT   Epitope Alignment
Variants
crQIlgQLQPALQTGT   subtype-specific susceptible form
Epitope Name Peptide 15
Species (MHC/HLA human

Variant Details

Showing 1 of 4 variants.


Variant ID.  2908
Epitope Seq.  xKQIMKQLQPALQTGT
Variant Seq.  crQIlgQLQPALQTGT
Mutations x/C K/R M/L K/G
Epitope Location x1C K2R M5L K6G
HXB2 Location x58C K59R M62L K63G
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype C
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note Consensus Clade-B peptide 15, crQIlgQLQPALQTGT, cross reacted to elicit a response from South African subjects carrying clade-C virus.

References

Zembe2011 Lycias Zembe, Wendy A. Burgers, Heather B. Jaspan, Linda-Gail Bekker, Helba Bredell, Gwynneth Stevens, Jill Gilmour, Josephine H. Cox, Patricia Fast, Peter Hayes, Eftyhia Vardas, Carolyn Williamson, and Clive M. Gray. Intra- and Inter-Clade Cross-Reactivity by HIV-1 Gag Specific T-Cells Reveals Exclusive and Commonly Targeted Regions: Implications for Current Vaccine Trials. PLoS One, 6(10):e26096, 2011. PubMed ID: 22022524. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health