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Found 1 matching record:

Displaying record number 58382

HXB2 Location  Gag(26-40)   Gag Epitope Map
View variants at this location
Epitope KKHYMLKHIVWASRE   Epitope Alignment
Variants
KKkYrLKHlVWASRE   subtype-specific non-susceptible form
Epitope Name Peptide 7
Species (MHC/HLA human

Variant Details

Showing 1 of 4 variants.


Variant ID.  2903
Epitope Seq.  KKHYMLKHIVWASRE
Variant Seq.  KKkYrLKHlVWASRE
Mutations H/K M/R I/L
Epitope Location H3K M5R I9L
HXB2 Location H28K M30R I34L
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype C
Variant Subtype A
Method CD8 T-cell Elispot - IFNy, Sequence
Note Consensus Clade-A peptide 7, KKkYrLKHlVWASRE, did not cross react to elicit a response from South African subjects carrying clade-C virus.

References

Zembe2011 Lycias Zembe, Wendy A. Burgers, Heather B. Jaspan, Linda-Gail Bekker, Helba Bredell, Gwynneth Stevens, Jill Gilmour, Josephine H. Cox, Patricia Fast, Peter Hayes, Eftyhia Vardas, Carolyn Williamson, and Clive M. Gray. Intra- and Inter-Clade Cross-Reactivity by HIV-1 Gag Specific T-Cells Reveals Exclusive and Commonly Targeted Regions: Implications for Current Vaccine Trials. PLoS One, 6(10):e26096, 2011. PubMed ID: 22022524. Show all entries for this paper.


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