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Displaying record number 58382

HXB2 Location Gag(26-40) Gag Epitope Map
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Epitope

KKHYMLKHIVWASRE

Epitope Alignment

Variants

{g}KKkYkLKHlVWASR subtype-specific non-susceptible form

Epitope Name Peptide 7

Species (MHC/HLA) human

Variant Details

Showing 1 of 4 variants.

Variant ID.	`2900`
Epitope Seq.	`{x}KKHYMLKHIVWASRE`
Variant Seq.	`{g}KKkYkLKHlVWASR`
Mutations	x/G I/L H/K M/K
Epitope Location	x1G I10L H4K M6K
HXB2 Location	x26G I35L H29K M31K
Mutation Type	SNSF: subtype-specific non-susceptible form
Epitope Subtype	C
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Consensus Clade-B peptide 7, {g}KKkYkLKHlVWASR, did not cross react to elicit a response from South African subjects carrying clade-C virus.

References

Zembe2011 Lycias Zembe, Wendy A. Burgers, Heather B. Jaspan, Linda-Gail Bekker, Helba Bredell, Gwynneth Stevens, Jill Gilmour, Josephine H. Cox, Patricia Fast, Peter Hayes, Eftyhia Vardas, Carolyn Williamson, and Clive M. Gray. Intra- and Inter-Clade Cross-Reactivity by HIV-1 Gag Specific T-Cells Reveals Exclusive and Commonly Targeted Regions: Implications for Current Vaccine Trials. PLoS One, 6(10):e26096, 2011. PubMed ID: 22022524. Show all entries for this paper.