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Found 1 matching record:

Displaying record number 58187

HXB2 Location  Gag(28-36)   Gag Epitope Map
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Epitope KYKLKHIVW   Epitope Alignment
Variants
KYrLKHIVW   epitope loss; literature escape
Epitope Name Gag28-36
Species (MHC/HLA human(A*24:02)

Variant Details

Showing all: 1 variant(s).


Variant ID.  2782
Epitope Seq.  KYKLKHIVW
Variant Seq.  KYrLKHIVW
Mutations K/R
Epitope Location K3R
HXB2 Location K30R
Mutation Type EL: epitope loss
LE: literature escape
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Chromium-release assay, Intracellular cytokine staining, Relative replication capacity assay, Tetramer binding
Note This K3R mutant was used for studies comparing CTL specific for mutants and WT KYKLKHIVW. The 3R mutant was unable to revert to WT in HLA-A*2402 minus subjects.

References

Akahoshi2012 Tomohiro Akahoshi, Takayuki Chikata, Yoshiko Tamura, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Selection and Accumulation of an HIV-1 Escape Mutant by Three Types of HIV-1-Specific Cytotoxic T Lymphocytes Recognizing Wild-Type and/or Escape Mutant Epitopes. J. Virol., 86(4):1971-1981, Feb 2012. PubMed ID: 22156528. Show all entries for this paper.


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