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Displaying record number 58187

HXB2 Location Gag(28-36) Gag Epitope Map
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Epitope

KYKLKHIVW

Epitope Alignment

Variants

KYrLKHIVW epitope loss; literature escape

Epitope Name Gag28-36

Species (MHC/HLA) human(A*24:02)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`2782`
Epitope Seq.	`KYKLKHIVW`
Variant Seq.	`KYrLKHIVW`
Mutations	K/R
Epitope Location	K3R
HXB2 Location	K30R
Mutation Type	EL: epitope loss LE: literature escape
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Chromium-release assay, Intracellular cytokine staining, Relative replication capacity assay, Tetramer binding
Note	This K3R mutant was used for studies comparing CTL specific for mutants and WT KYKLKHIVW. The 3R mutant was unable to revert to WT in HLA-A*2402 minus subjects.

References

Akahoshi2012 Tomohiro Akahoshi, Takayuki Chikata, Yoshiko Tamura, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Selection and Accumulation of an HIV-1 Escape Mutant by Three Types of HIV-1-Specific Cytotoxic T Lymphocytes Recognizing Wild-Type and/or Escape Mutant Epitopes. J. Virol., 86(4):1971-1981, Feb 2012. PubMed ID: 22156528. Show all entries for this paper.