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Found 1 matching record:

Displaying record number 58010

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLYNTVATL   Epitope Alignment
Variants
SLYNTiATL   HLA association; processing
Epitope Name SL9
Species (MHC/HLA human(A*02)

Variant Details

Showing 1 of 5 variants.


Variant ID.  2707
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTiATL
Mutations V/I
Epitope Location V6I
HXB2 Location V82I
Mutation Type A: HLA association
P: processing
Epitope Subtype B
Variant Subtype B
Note A2-SL9 has known HLA-associated mutants (T8V, Y3F, V6I, V6I/T8V, Y3F/V6I). All 5 mutants displayed severely reduced half-lives.

References

Lazaro2011 Estibaliz Lazaro, Carl Kadie, Pamela Stamegna, Shao Chong Zhang, Pauline Gourdain, Nicole Y. Lai, Mei Zhang, Sergio A. Martinez, David Heckerman, and Sylvie Le Gall. Variable HIV Peptide Stability in Human Cytosol Is Critical to Epitope Presentation and Immune Escape. J. Clin. Invest., 121(6):2480-2492, Jun 2011. PubMed ID: 21555856. Show all entries for this paper.


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