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Found 1 matching record:

Displaying record number 57936

HXB2 Location  Gag(197-205)   Gag Epitope Map
View variants at this location
Epitope AMQMLKDTI   Epitope Alignment
Variants
AMefLKDTa   diminished HLA binding or increased off-rate
Epitope Name G1
Species (MHC/HLA mouse(H-2Kd)

Variant Details

Showing all: 1 variant(s).


Variant ID.  2665
Epitope Seq.  AMQMLKDTI
Variant Seq.  AMefLKDTa
Mutations Q/E M/F I/A
Epitope Location Q3E M4F I9A
HXB2 Location Q199E M200F I205A
Mutation Type DHB: diminished HLA binding or increased off-rate
Epitope Subtype A
Variant Subtype A
Method HLA binding
Note Artificially-produced mutant AMefLKDTa was created to abrogate the anchor residues of epitope AMQMLKDTI. Loss of HLA binding was confirmed.

References

Im2011 Eung-Jun Im, Jessie P. Hong, Yaowaluck Roshorm, Anne Bridgeman, Sven Létourneau, Peter Liljeström, Mary Jane Potash, David J. Volsky, Andrew J. McMichael, and Tomáš Hanke. Protective Efficacy of Serially Up-Ranked Subdominant CD8+ T Cell Epitopes against Virus Challenges. PLoS Pathog., 7(5):e1002041, May 2011. PubMed ID: 21625575. Show all entries for this paper.


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