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HIV Molecular Immunology Database

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Found 1 matching record:

Displaying record number 201783

HXB2 Location  Env(172-188)   Env Epitope Map
View variants at this location
Epitope VHALFYKLDIVPIEDNK   Epitope Alignment
Variants
VHALFYKLDlVqIEDNK   escape documented in this paper; non-susceptible form
Epitope Name peptide 32, pep 32
Species (MHC/HLA human

Variant Details

Showing 1 of 9 variants.


Variant ID.  26
Epitope Seq.  VHALFYKLDIVPIEDNK
Variant Seq.  VHALFYKLDlVqIEDNK
Mutations I/L P/Q
Epitope Location I10L P12Q
HXB2 Location I181L P183Q
Mutation Type E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B, CRF01_AE
Variant Subtype B, CRF01_AE
Method CD8 T-cell Elispot - IFNy
Note Peptide 32 variant VHALFYKLDlVqIEDNK, completely abrogated CTL response in all 4 previously vaccinated subjects from RV144 that were tested.

References

Ratto-Kim2015 Silvia Ratto-Kim, Mark S. de Souza, Jeffrey R. Currier, Nicos Karasavvas, John Sidney, Morgane Rolland, Anais Valencia-Micolta, Sirinan Madnote, Alessandro Sette, Sorachai Nitayaphan, Punnee Pitisuttuthum, Jaranit Kaewkungwal, Supachai Rerks-Ngarm, Robert O'Connell, Nelson Michael, Merlin L. Robb, Mary Marovich, and Jerome H. Kim. Identification of Immunodominant CD4-Restricted Epitopes Co-Located with Antibody Binding Sites in Individuals Vaccinated with ALVAC-HIV and AIDSVAX B/E. PLoS One, 10(2):e0115582, 2015. PubMed ID: 25665096. Show all entries for this paper.


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