Search the Epitope Variant and Escape Mutation Database

Help

Found 1 matching record:

Displaying record number 57258

HXB2 Location Gag(147-155) Gag Epitope Map
View variants at this location

Epitope

ISPRTLNAW

Epitope Alignment

Variants

lSPRTLNAW susceptible form

Epitope Name IW9

Species (MHC/HLA) human(B*57)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`2552`
Epitope Seq.	`ISPRTLNAW`
Variant Seq.	`lSPRTLNAW`
Mutations	I/L
Epitope Location	I1L
HXB2 Location	I147L
Mutation Type	SF: susceptible form
Epitope Subtype	A1
Variant Subtype	D
Method	CD8 T-cell Elispot - IFNy
Note	Previously-documented Clade D ISPRTLNAW escape variant I147L was not selected against among B*57+ clade A1 subjects. These subjects responded similarly to 147I and 147L.

References

McKinnon2009 Lyle R. McKinnon, Rupert Capina, Harold Peters, Mark Mendoza, Joshua Kimani, Charles Wachihi, Anthony Kariri, Makobu Kimani, Meika Richmond, Sandy Koesters Kiazyk, Keith R. Fowke, Walter Jaoko, Ma Luo, T Blake Ball, and Francis A. Plummer. Clade-Specific Evolution Mediated by HLA-B*57/5801 in Human Immunodeficiency Virus Type 1 Clade A1 p24. J Virol, 83(23):12636-12642, Dec 2009. PubMed ID: 19759140. Show all entries for this paper.