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Found 1 matching record:

Displaying record number 57258

HXB2 Location  Gag(147-155)   Gag Epitope Map
View variants at this location
Epitope ISPRTLNAW   Epitope Alignment
Variants
lSPRTLNAW   susceptible form
Epitope Name IW9
Species (MHC/HLA human(B*57)

Variant Details

Showing all: 1 variant(s).


Variant ID.  2552
Epitope Seq.  ISPRTLNAW
Variant Seq.  lSPRTLNAW
Mutations I/L
Epitope Location I1L
HXB2 Location I147L
Mutation Type SF: susceptible form
Epitope Subtype A1
Variant Subtype D
Method CD8 T-cell Elispot - IFNy
Note Previously-documented Clade D ISPRTLNAW escape variant I147L was not selected against among B*57+ clade A1 subjects. These subjects responded similarly to 147I and 147L.

References

McKinnon2009 Lyle R. McKinnon, Rupert Capina, Harold Peters, Mark Mendoza, Joshua Kimani, Charles Wachihi, Anthony Kariri, Makobu Kimani, Meika Richmond, Sandy Koesters Kiazyk, Keith R. Fowke, Walter Jaoko, Ma Luo, T Blake Ball, and Francis A. Plummer. Clade-Specific Evolution Mediated by HLA-B*57/5801 in Human Immunodeficiency Virus Type 1 Clade A1 p24. J Virol, 83(23):12636-12642, Dec 2009. PubMed ID: 19759140. Show all entries for this paper.


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